North American Registration Authorities Ontology
type: Ontology
abstract: The registration authorities ontology provides the registration authorities, registries and related codes that are specific to the Canada, Mexico, and the United States that are needed for identification of substances and medicinal products.
license: https://opensource.org/licenses/MIT
imports: ISO11238-Substances
imports: NorthAmericanRegulatoryAgencies
imports: ChangeManagement
imports: AnnotationVocabulary
imports: Collections
imports: ContextualDesignators
imports: GovernmentEntities
imports: Identifiers
imports: Organizations
imports: PartiesAndSituations
imports: ProductsAndServices
imports: RegistrationAuthorities
imports: RegulatoryAgencies
imports: RolesAndCompositions
imports: ISO3166-1-CountryCodes
imports: MultipleVocabularyFacility
version IRI: NorthAmericanRegistrationAuthorities
change note: The https://spec.pistoiaalliance.org/idmp/ontology/ISO/NorthAmericanJurisdiction/NorthAmericanRegistrationAuthorities.rdf version of this ontology was revised to normalize the use of hasTextualName from MVF rather than from LCC.
scope note: Note that jurisdiction-specific counterparties and codes are specified in subordinate ontologies supporting those jurisdictions.
has maturity level: Provisional
copyright: Copyright (c) 2022-2024 EDM Council, Inc.
copyright: Copyright (c) 2022-2024 Pistoia Alliance, Inc.

American Chemical Society
type: NamedIndividual
type: FormalOrganization
definition: scientific society based in the United States that supports scientific inquiry in the field of chemistry
abbreviation: ACS
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.2
explanatory note: Founded in 1876 at New York University, the ACS has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio.
is domiciled in: UnitedStatesOfAmerica

American Chemical Society Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: American Chemical Society (ACS) in its role as a Registration Authority (RA), which is a function of the ACS for registration of substances in the CAS Registry
abbreviation: ACS RA
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.2
manages: Chemical Abstracts Service registry
provides: Chemical Abstracts Service
is played by: American Chemical Society

CAS registry number
type: Class
subclass of: SubstanceCode
subclass of: Restriction
  on property: hasRegistrationAuthority
  has value: American Chemical Society Registration Authority
subclass of: Restriction
  on property: isRegisteredIn
  has value: Chemical Abstracts Service registry
subclass of: Restriction
  on property: identifies
  some values from: Substance
source: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clauses 3.9, A.1.2
definition: unique numerical identifier of a substance in the CAS Registry system
note: The numbers are sequential and are assigned as a substance enters the registry system. The numbers do not have a common length and lengths can be up to 10 digits. Each CAS number contains a single check digit. The assignment of chemical names is done according to the chemical nomenclature rules for CA index names, which is slightly different from the internationally standard IUPAC names, according to the rules of IUPAC.
scope note: Polymers frequently only have one CAS registry number associated with them, regardless of differences in molecular mass or other defining elements.
synonym: CAS Registry Number
synonym: CAS number
usage note: Although CAS numbers are widely used, they cannot be freely used. CAS has guidelines on the use of CAS registry numbers and has attempted to restrict their use in publicly available databases.

Centers for Disease Control and Prevention
type: NamedIndividual
type: GovernmentAgency
acronym: CDC
direct source: www.cdc.gov
is constituent of: U.S. Department of Health and Human Services

Centers for Disease Control and Prevention Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: Centers for Disease Control and Prevention in its role as a Registration Authority (RA)
is played by: Centers for Disease Control and Prevention

Chemical Abstracts Service
type: NamedIndividual
type: RegistrationService
definition: service that provides a periodical index that provides numerous tools such as SciFinder as well as tagged keywords, summaries, indexes of disclosures, and structures of compounds in recently published scientific documents
abbreviation: CAS
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.2
explanatory note: Approximately 8,000 journals, technical reports, dissertations, conference proceedings, and new books, available in at least 50 different languages, are monitored yearly, as are patent specifications from 27 countries and two international organizations. Chemical Abstracts ceased print publication on January 1, 2010.
is provided by: American Chemical Society Registration Authority

Chemical Abstracts Service registry
type: NamedIndividual
type: Registry
definition: registry that contains information on more than 130 million organic and inorganic substances, and more than 64 million protein and nucleic acid sequences
abbreviation: CAS Chemical Registry System
abbreviation: CAS Registry
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.2
explanatory note: The sequence information comes from CAS and GenBank, produced by the National Institutes of Health. The chemical information is produced by CAS, and is prepared by the CAS Registry System, which identifies each compound with a specific CAS registry number, index name, and graphic representation of its chemical structure. The assignment of chemical names is done according to the chemical nomenclature rules for CA index names, which is slightly different from the internationally standard IUPAC names, according to the rules of IUPAC.
is managed by: American Chemical Society Registration Authority
has textual name: Chemical Abstracts Service Registry

Chemical Abstracts Service registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: Chemical Abstracts Service registry
subclass of: Restriction
  on property: comprises
  some values from: CAS registry number
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the Chemical Abstracts Service (CAS) registry, prepared by the CAS Registry System, that identifies each compound with a specific CAS registry number, index name, and graphic representation of its chemical structure
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.2

ClinicalTrials.gov
type: NamedIndividual
type: Registry
definition: database of privately and publicly funded clinical studies conducted around the world
direct source: clinicaltrials.gov
is managed by: National Library of Medicine Registration Authority
has textual name: ClinicalTrials.gov

Cosmetic Ingredient Review
type: NamedIndividual
type: FormalOrganization
definition: independent scientific review board in the United States that reviews and assesses the safety of ingredients in an open, unbiased, and expert manner, and publishes the results in the peer-reviewed scientific literature
abbreviation: CIR
direct source: www.cir-safety.org
explanatory note: The Cosmetic Ingredient Review was established in 1976 by the industry trade association (then the Cosmetic, Toiletry, and Fragrance Association, now the Personal Care Products Council), with the support of the U.S. Food and Drug Administration and the Consumer Federation of America. Although funded by the Council, CIR, the Expert Panel for Cosmetic Ingredient Safety, and the review process are independent from the Council and the cosmetics industry. CIR and the Expert Panel for Cosmetic Ingredient Safety operate under a set of procedures.
is domiciled in: UnitedStatesOfAmerica

Cosmetic Ingredient Review Database
type: NamedIndividual
type: Registry
definition: repository that provides reviews and assesses the safety of ingredients in an open, unbiased, and expert manner, and publish the results in the peer-reviewed scientific literature
direct source: www.cir-safety.org
is managed by: Cosmetic Ingredient Review Registration Authority
has textual name: Cosmetic Ingredient Review Database

Cosmetic Ingredient Review Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: Cosmetic Ingredient Review (CIR) in its role as a Registration Authority (RA), for content that reflects the review and assessment of the safety of ingredients
abbreviation: CIR RA
manages: Cosmetic Ingredient Review Database
is played by: UnitedStatesFoodAndDrugAdministration

Department of Agriculture Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: United States Department of Agriculture in its role as a Registration Authority (RA)
manages: Germplasm Resources Information Network
is played by: UnitedStatesDepartmentOfAgriculture

U.S. Department of Health and Human Services
type: NamedIndividual
type: GovernmentDepartment
direct source: www.hhs.gov

Drug Bank
type: NamedIndividual
type: Registry
definition: online database containing information on drugs and drug targets
direct source: go.drugbank.com
is managed by: OMx Personal Health Analytics, Inc. as registration authority
has textual name: Drug Bank

Food and Drug Administration Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: Food and Drug Administration (FDA) in its role as a Registration Authority (RA), which is a function of the G-SRS for registration of substances in the FDA/USP Global Substance Registry System
abbreviation: FDA G-SRS RA
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.5
manages: Global Substance Registration System
is played by: UnitedStatesFoodAndDrugAdministration

Germplasm Resources Information Network
type: NamedIndividual
type: Registry
definition: repository that documents animal, microbial, and plant collections through informational pages, searchable databases, and links to USDA-ARS projects that curate the collections
abbreviation: GRIN
direct source: www.ars-grin.gov
is managed by: Department of Agriculture Registration Authority
has textual name: Germplasm Resources Information Network

Global Substance Registration System
type: NamedIndividual
type: Registry
definition: registry that was developed to assist regulators in managing substance information
abbreviation: G-SRS
abbreviation: GSRS
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.5
explanatory note: GSRS was designed to facilitate global monitoring of human and animal medicinal, food, tobacco, and cosmetic products. GSRS provides unique substance identifiers consistent with the ISO 11238 standard. FDA's GSRS specifically generates the Unique Ingredient Identifiers (UNIIs) used in electronic listing and other regulatory activities.
is managed by: Food and Drug Administration Registration Authority
has textual name: Global Substance Registration System - GSRS

Global Substance Registry System registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: Global Substance Registration System
subclass of: Restriction
  on property: comprises
  some values from: unique ingredient number
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the Global Substance Registry System (GSRS) registry, that includes the Unique Ingredient Identifiers (UNIIs) used in electronic listing and other regulatory activities
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.5

global substance registration service
type: NamedIndividual
type: RegistrationService
definition: service with detailed business rules for data entry and generation of UNIIs for both simple and complex substances
abbreviation: G-SRS service
adapted from: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.5
is provided by: Food and Drug Administration Registration Authority

Integrated Taxonomic Information System
type: NamedIndividual
type: Registry
alt label: Interagency Taxonomic Information System
definition: registry that provides standardized information about the vascular plants, mosses, liverworts, hornworts, and lichens of the U.S. and its territories
abbreviation: ITIS
explanatory note: The ITIS includes names, plant symbols, checklists, distributional data, species abstracts, characteristics, images, crop information, automated tools, onward Web links, and references. This information primarily promotes land conservation in the United States and its territories, but academic, educational, and general use is encouraged.
is managed by: Integrated Taxonomic Information System Registration Authority
has textual name: Integrated Taxonomic Information System

Integrated Taxonomic Information System registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: Integrated Taxonomic Information System
subclass of: Restriction
  on property: comprises
  some values from: Integrated Taxonomic Information System Taxonomic Serial Number
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the Integrated Taxonomic Information System registry comprised of a Taxonomix Serial Number used in electronic listing and other regulatory activities
abbreviation: ITIS entry

ITIS Organization
type: NamedIndividual
type: FormalOrganization
definition: group of agencies consisting of a steering committee and technical working committees for database design and quality management for the content provided in the Integrated Taxonomic Information System
explanatory note: These agencies signed a Memorandum of Understanding and have formed a Steering Committee that directs two technical work groups - the Database Work Group (DWG) and the Taxonomy Work Group (TWG). The DWG is responsible for the database design and overseeing development of the system to meet the requirements of the ITIS partners. The TWG is responsible for the quality and integrity of the database information. In addition to the database, the working groups have created "Taxonomic Workbench" software designed for easy entry and manipulation of taxonomic data.

Integrated Taxonomic Information System Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: Integrated Taxonomic Information System (ITIS) in its role as a Registration Authority (RA), which is multi-agency organization that involves specialists from around the world to assemble scientific names and their taxonomic relationships, and distribute that data through publicly available software
abbreviation: ITIS
manages: Integrated Taxonomic Information System
is played by: ITIS Organization

Integrated Taxonomic Information System Taxonomic Serial Number
type: Class
subclass of: RegisteredIdentifier
subclass of: Restriction
  on property: isDefinedIn
  has value: Integrated Taxonomic Information System
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: unique identifier for an entry in the Integrated Taxonomic Information System registry used in electronic listing and other regulatory activities
synonym: TSN

Inventory of Effective Food Contact Substance Notifications
type: NamedIndividual
type: Registry
definition: repository that lists effective pre-market notifications for food contact substances that have been demonstrated to be safe for their intended use
direct source: inventory-effective-food-contact-substance-fcs-notifications
is managed by: Food and Drug Administration Registration Authority
has textual name: Inventory of Effective Food Contact Substance (FCS) Notifications

LiverTox
type: NamedIndividual
type: Registry
definition: repository published by the U.S. National Library of Medicine (NLM) that provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury attributable to prescription and nonprescription medications and selected herbal and dietary supplements
direct source: NBK547852
explanatory note: LiverTox is also known as the Clinical and Research Information on Drug-Induced Liver Injury library.
is managed by: National Library of Medicine Registration Authority
has textual name: LiverTox

Medical Subject Headings
type: NamedIndividual
type: Registry
definition: National Library of Medicine (NLM) controlled vocabulary and thesaurus used for indexing articles for PubMed
abbreviation: MeSH
direct source: https://www.ncbi.nlm.nih.gov/mesh/
is managed by: National Library of Medicine Registration Authority
has textual name: Medical Subject Headings

Medical Subject Headings registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: Medical Subject Headings
subclass of: Restriction
  on property: comprises
  some values from: medical subject headings unique identifier
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the Medical Subject Headings (MeSH) registry that includes the Medical Subject Headings Unique Identifier (MeSH Unique ID) used in electronic listing and other regulatory activities

medical subject headings unique identifier
type: Class
subclass of: SubstanceCode
subclass of: Restriction
  on property: isRegisteredIn
  has value: Medical Subject Headings
subclass of: Restriction
  on property: hasRegistrationAuthority
  has value: National Library of Medicine Registration Authority
subclass of: Restriction
  on property: identifies
  some values from: Substance
definition: alpha-numeric string that is used to identify records in the Medical Subject Headings registry
note: MeSH Unique ID finds Descriptor, Qualifier, and Supplemental Concept Records by their Record Unique Identifier.
synonym: MeSH Unique ID

National Cancer Institute
type: NamedIndividual
type: GovernmentAgency
definition: institute that is part of the U.S. National Institutes of Health (NIH) that is the federal government's principal agency for cancer research and training
abbreviation: NCI

National Cancer Institute registration authority
type: NamedIndividual
type: RegistrationAuthority
definition: National Cancer Institute in its role as a Registration Authority (RA)
manages: National Cancer Institute Thesaurus
is played by: National Cancer Institute

National Cancer Institute Thesaurus
type: NamedIndividual
type: Registry
definition: registry that provides reference terminology for many NCI and other systems that is widely used across the healthcare industry as the basis for vocabulary and terminology work
note: It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.
abbreviation: NCIt
direct source: ncitbrowser
is managed by: National Cancer Institute registration authority
has textual name: NCI Thesaurus

National Cancer Institute Thesaurus Code
type: Class
subclass of: RegisteredIdentifier
subclass of: Restriction
  on property: hasRegistrationAuthority
  has value: National Cancer Institute registration authority
subclass of: Restriction
  on property: isRegisteredIn
  has value: National Cancer Institute Thesaurus
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: alpha-numeric string that is used to identify records in the National Center for Biotechnology Information Taxonomy registry
synonym: NCI Thesaurus Code

National Cancer Institute Thesaurus registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: National Cancer Institute Thesaurus
subclass of: Restriction
  on property: comprises
  some values from: National Center for Biotechnology Information Taxonomy identifier
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the National Cancer Institute Thesaurus that includes the National Cancer Institute Thesaurus Code used in electronic listing and other regulatory activities

National Center For Biotechnology Information
type: NamedIndividual
type: GovernmentDepartment
definition: organization that is part of the U.S. National Library of Medicine, National Institutes of Health (NIH) that advances science and health by providing access to biomedical and genomic information
abbreviation: NCBI
is constituent of: National Library of Medicine

National Center for Biotechnology Information Gene Database
type: NamedIndividual
type: Registry
definition: registry published by the National Center For Biotechnology Information that integrates information from a wide range of species
abbreviation: Gene
direct source: gene
is managed by: National Library of Medicine Registration Authority
has textual name: National Center for Biotechnology Information Gene Database

National Center For Biotechnology Information registration authority
type: NamedIndividual
type: RegistrationAuthority
definition: National Center For Biotechnology Information in its role as a Registration Authority (RA)
manages: National Center for Biotechnology Information Taxonomy Database
is played by: National Center For Biotechnology Information

National Center for Biotechnology Information Taxonomy Database
type: NamedIndividual
type: Registry
definition: registry that is a curated classification and nomenclature for all of the organisms in the public sequence databases, representing roughly 10 percent of the described species of life on the planet
direct source: taxonomy
is managed by: National Center For Biotechnology Information registration authority
has textual name: NCBI Taxonomy

National Center for Biotechnology Information Taxonomy Database registry entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isIncludedIn
  has value: National Center for Biotechnology Information Taxonomy Database
subclass of: Restriction
  on property: comprises
  some values from: National Center for Biotechnology Information Taxonomy identifier
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the National Center for Biotechnology Information Taxonomy Database, that includes the National Center for Biotechnology Information Taxonomy Database Unique Identifier used in electronic listing and other regulatory activities

National Center for Biotechnology Information Taxonomy identifier
type: Class
subclass of: RegisteredIdentifier
subclass of: Restriction
  on property: hasRegistrationAuthority
  has value: National Center For Biotechnology Information registration authority
subclass of: Restriction
  on property: isRegisteredIn
  has value: National Center for Biotechnology Information Taxonomy Database
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: alpha-numeric string that is used to identify records in the National Center for Biotechnology Information Taxonomy registry
synonym: NCBI Taxonomy ID

National Drug File - Reference Terminology
type: NamedIndividual
type: Registry
definition: legacy registry that was published by the U.S. Department of Veterans Affairs, Veterans Health Administration, providing standard names for (1) mechanism of action, (2) Physiologic Effect and (3) Structural Class for drugs NDF-RT is part of the Federal Medication Terminologies.
scope note: NDF-RT is part of the Federal Medication Terminologies. Publication of NDF-RT has ended. The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File.
abbreviation: NDF-RT
direct source: https://evs.nci.nih.gov/ftp1/NDF-RT/
is managed by: Veterans Health Administration Registration Authority
has textual name: National Drug File - Reference Terminology (NDF-RT)

National Library of Medicine
type: NamedIndividual
type: GovernmentAgency
definition: U.S. government institute that is part of the National Institutes of Health, responsible for collecting, curating and providing access to medicinal and related scientific publications
abbreviation: NLM

National Library of Medicine Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: National Library of Medicine (NLM) in its role as a Registration Authority (RA)
manages: Medical Subject Headings
is played by: National Library of Medicine

National Plant Data Team
type: NamedIndividual
type: GovernmentDepartment
definition: organization within the U.S. Department of Agriculture that focuses on plant data collection, content, quality control, integration, dissemination, and interpretation for National Resources Conservation Service (NRCS) use in conservation practices
adapted from: https://plants.usda.gov/home/team
is constituent of: UnitedStatesDepartmentOfAgriculture

OMx Personal Health Analytics, Inc.
type: NamedIndividual
type: LegalEntity
definition: party that was a spin-off from work conducted by the University of Alberta to manage products related to the DrugBank repository

OMx Personal Health Analytics, Inc. as registration authority
type: NamedIndividual
type: RegistrationAuthority
definition: OMx Personal Health Analytics in its role as the registration authority for the DrugBank Online repository
manages: Drug Bank
is played by: OMx Personal Health Analytics, Inc.

orphan drug product designation database
type: NamedIndividual
type: Registry
direct source: index.cfm
is managed by: Food and Drug Administration Registration Authority
has textual name: Orphan Drug Product designation database

Pesticide Product Information System
type: NamedIndividual
type: Registry
definition: registry published by the U.S. Environmental Protection Agency that contains information concerning all pesticide products registered in the United States
abbreviation: PPIS
direct source: pesticide-product-information-system-ppis
has textual name: Pesticide Product Information System

Plant List of Accepted Nomenclature, Taxonomy, and Symbols
type: NamedIndividual
type: Registry
definition: registry published by the U.S. Department of Agriculture that provides standardized information about the vascular plants, mosses, liverworts, hornworts, and lichens of the U.S. and its territories
note: The registry includes names, plant symbols, checklists, distributional data, species abstracts, characteristics, images, crop information, automated tools, onward Web links, and references. This information primarily promotes land conservation in the United States and its territories, but academic, educational, and general use is encouraged.
abbreviation: PLANTS Database
abbreviation: USDA PLANTS
direct source: https://plants.usda.gov/home
is managed by: Department of Agriculture Registration Authority
has textual name: Plant List of Accepted Nomenclature, Taxonomy, and Symbols

Plant List of Accepted Nomenclature, Taxonomy, and Symbols entry
type: Class
subclass of: RegistryEntry
subclass of: Restriction
  on property: isDefinedIn
  has value: Integrated Taxonomic Information System
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: entry in the Plant List of Accepted Nomenclature, Taxonomy, and Symbols registry used in electronic listing and other regulatory activities

Plant List of Accepted Nomenclature, Taxonomy, and Symbols symbol
type: Class
subclass of: RegisteredIdentifier
subclass of: Restriction
  on property: isDefinedIn
  has value: Plant List of Accepted Nomenclature, Taxonomy, and Symbols
subclass of: Restriction
  on property: appliesTo
  some values from: Substance
definition: unique identifier for an entry in the Plant List of Accepted Nomenclature, Taxonomy, and Symbols registry used in electronic listing and other regulatory activities

PubChem
type: NamedIndividual
type: Registry
definition: registry that is an open chemistry database at the National Institutes of Health (NIH)
direct source: pubchemdocs.ncbi.nlm.nih.gov
is managed by: National Library of Medicine Registration Authority
has textual name: PubChem

RxNorm
type: NamedIndividual
type: Registry
definition: registry published by the U.S. National Library of Medicine that provides normalized names for clinical drugs and links its names to many of the drug vocabularies commonly used in pharmacy management and drug interaction software, including those of First Databank, Micromedex, and Gold Standard Drug Database
note: By providing links between these vocabularies, RxNorm can mediate messages between systems not using the same software and vocabulary.
direct source: rxnorm
is managed by: National Library of Medicine Registration Authority
has textual name: RxNorm

U.S. Pharmacopeia Medicines Compendium
type: NamedIndividual
type: Registry
definition: all-online compendium that provides monographs and reference materials for chemical and biological medicines and excipients legally marketed in any country
abbreviation: USP-MC
direct source: https://www.uspnf.com/notices/archived-call-candidates-usp-medicines-compendium-biologics-expert-committee
has textual name: U.S. Pharmacopeia Medicines Compendium

unique ingredient number
type: Class
subclass of: SubstanceCode
subclass of: Restriction
  on property: hasRegistrationAuthority
  has value: Food and Drug Administration Registration Authority
subclass of: Restriction
  on property: isRegisteredIn
  has value: Global Substance Registration System
subclass of: Restriction
  on property: identifies
  some values from: Substance
definition: 10-character, randomly generated alpha-numeric string that is used to identify substances in medicinal products in the FDA Global Substance Registration System (G-SRS)
note: The first nine characters are randomly generated followed by a check character. The integrity check on the UNII is stronger than both the EC# and the CAS Registry Number because of the random generation from a large number of potential UNIIs and the fact that there are 36 possible check characters compared to 10 with both the EC# and CAS Registry Number.
scope note: The UNII is freely available for use and there is a mechanism whereby a manufacturer can petition for the generation of a UNII through the FDA. The system has the capability for both public and restricted access to information, and can be adapted to produce specified substance identifiers.
abbreviation: UNII
direct source: ISO 11238:2018 Health informatics - Identification of medicinal products (IDMP) - Data elements and structures for the unique identification and exchange of regulated information on substances, clause A.1.5

University of California, San Franciso Federal Drug Administration TransPortal
type: NamedIndividual
type: Registry
alt label: UCSF-FDA TransPortal
definition: standardized and publicly accessible website for archiving and disseminating information on mammalian transporter interactions with xenobiotics, including pharmaceuticals and environmental chemicals
direct source: transportal.compbio.ucsf.edu
has textual name: University of California, San Franciso Federal Drug Administration TransPortal

Veterans Health Administration
type: NamedIndividual
type: GovernmentAgency
definition: U.S. government healthcare organization that provides primary care, specialized care, and related medical and social support services to American veterans
abbreviation: VHA
direct source: veterans-health-administration

Veterans Health Administration Registration Authority
type: NamedIndividual
type: RegistrationAuthority
definition: Veterans Health Administration in its role as a Registration Authority (RA)
manages: National Drug File - Reference Terminology
is played by: Veterans Health Administration